Laboratory of Autoimmunity and Immunopharmacology

Click Here: Full list of publications in PubMed

Representative Publications

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1. Chia oil prevents chemical and immune-mediated inflammatory responses in mice: Evidence for the underlying mechanisms. Cavalli J, Freitas MA, Gonçalves EC, Fadanni GP, Santos AA, Raposo NR, Dutra RC.  Food Research International.  2021, 110703.
2. Pramipexole, a dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice. Martins CP, Paes RS, Baldasso GM, Ferrarini EG, Scussel R, Zaccaron RP, Machado-de-Ávila RA, Silveira PCL,  Dutra RC. Neural Regeneration Research. 2022, 17(2):450.
3. Plinia cauliflora (Mart.) Kausel: toxicological assays, biological activities, and elemental analysis of organic compounds. Assis PMD, Dutra RC, Amarante CBD, Chaves MDGAM, Moreira CPDS, Brandão MAF, Raposo NRB. Natural product research. 2021, 35(10), 1727-1731.
4. Exercise Reduces Pain and Deleterious Histological Effects in Fibromyalgia-like Model. Ferrarini EG, Gonçalves ECD, Menegasso JF, Rabelo BD, Felipetti FA, Dutra RC. Neuroscience. 2021, 465:46.
5. Involvement of Opioid System and TRPM8/TRPA1 Channels in the Antinociceptive Effect of Spirulina platensis. Freitas MA, Vasconcelos A, Gonçalves ECD, Ferrarini EG, Vieira GB, Cicia D, Cola M, Capasso R, Dutra RC. Biomolecules. 2021, 11(4):592.
6. A closer look at cannabimimetic terpenes, polyphenols, and flavonoids: a promising road forward. Cavalli J, Dutra RC. Neural Regeneration Research. 2021, 16(7):1433.
7. Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor. Vieira G, Cavalli J, Gonçalves ECD, Braga SFP, Ferreira RS, Santos ARS, Cola M, Raposo NRB, Capasso R, Dutra RC. Biomolecules. 2020, 20;10(5):792.
8. Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant. Gonçalves ECD, Baldasso GM, Bicca MA, Paes RS, Capasso R, Dutra RC. Molecules. 2020, 29;25(7):1567.
9. Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model. Gonçalves ECD, Vieira G, Gonçalves TR, Simões RR, Brusco I, Oliveira SM, Calixto JB, Cola M, Santos ARS, Dutra RC. Cell Mol Neurobiol. 2020. 
10. In silico, in vitro and in vivo studies indicate resveratrol analogue as a potential alternative for neuroinflammatory disorders. de Assis P M, Fávero A, Menegasso JF, Meinel RS, Marion GM, Nunes VSP, Goliatt PVZC, da Silva AD, Dutra RC, Raposo NRB. Life sciences. 2020, 249:117538.
11. Citral Inhibits the Inflammatory Response and Hyperalgesia in Mice: The Role of TLR4, TLR2/Dectin-1, and CB2 Cannabinoid Receptor/ATP-Sensitive K⁺ Channel Pathways. Gonçalves ECD, Assis PM, Junqueira LA, Cola M, Santos ARS, Raposo NRB, Dutra RC. J Nat Prod. 2020, 24;83(4):1190-1200. 
12. Cannabinoid receptors as therapeutic targets for autoimmune diseases: where do we stand? Gonçalves ED, Dutra RC. Drug Discov Today. 2019;24(9):1845-1853. 
13. Photobiomodulation Therapy Improves Acute Inflammatory Response in Mice: the Role of Cannabinoid Receptors/ATP-Sensitive K⁺ Channel/p38-MAPK Signalling Pathway. Neves LMS, Gonçalves ECD, Cavalli J, Vieira G, Laurindo LR, Simões RR, Coelho IS, Santos ARS, Marcolino AM, Cola M, Dutra RC. Mol Neurobiol. 2018;55(7):5580-5593. 
14. Effects of simvastatin beyond dyslipidemia: Exploring its antinociceptive action in an animal model of complex regional pain syndrome-type I. Vieira G, Cavalli J, Gonçalves EC, Gonçalves TR, Laurindo LR, Cola M, Dutra RC. Frontiers in pharmacology. 2017, 8:584.
15. (-)-β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis. Alberti TB, Barbosa WL, Vieira JL, Raposo NR, Dutra RC. Int J Mol Sci. 2017 1;18(4):691.
16. Kinin receptors: Key regulators of autoimmunity. Dutra RC. Autoimmun Rev. 2017;16(2):192-207.
17. Antidepressant-like effect of pramipexole in an inflammatory model of depression. Lieberknecht V, Cunha MP, Junqueira SC, Coelho IDS, de Souza LF, Dos Santos ARS, Rodrigues ALS,  Dutra RC, Dafre AL.  Behavioural brain research. 2017, 320:365.
18.  Physical Exercise Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Peripheral Immune Response and Blood-Brain Barrier Disruption. Souza PS, Gonçalves ED, Pedroso GS, Farias HR, Junqueira SC, Marcon R, Tuon T, Cola M, Silveira PCL, Santos AR, Calixto JB, Souza CT, de Pinho RA, Dutra RC. Mol Neurobiol. 2017;54(6):4723-4737. 
19. Inosine, an endogenous purine nucleoside, suppresses immune responses and protects mice from experimental autoimmune encephalomyelitis: a role for A2A adenosine receptor. Junqueira SC, Coelho IDS, Lieberknecht V, Cunha MP, Calixto JB, Rodrigues ALS, Dos Santos ARS, Dutra RC. Molecular neurobiology. 2017, 54(5):3271.
20. Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives. Dutra RC, Campos MM, Santos AR, Calixto JB. Pharmacol Res. 2016, 112:4-29. 
21. Pramipexole, a Dopamine D2/D3 Receptor-Preferring Agonist, Prevents Experimental Autoimmune Encephalomyelitis Development in Mice. Lieberknecht V, Junqueira SC, Cunha MP, Barbosa TA, de Souza LF, Coelho IS, Santos AR, Rodrigues AL, Dafré AL, Dutra RC. Mol Neurobiol. 2017, 54(2):1033. 
22. Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson’s Disease. Tuon T, Souza PS, Santos MF, Pereira FT, Pedroso GS, Luciano TF, De Souza CT, Dutra RC, Silveira PC, Pinho RA. Oxid Med Cell Longev. 2015, 2015:261809.